Announcement

Collapse
No announcement yet.

Study restores kidney function in rodents with CKD

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Study restores kidney function in rodents with CKD

    Cell-enriched primary renal cells improve survival and augment kidney function in CKD rodents

    Tengion, Inc. (Nasdaq: TNGN), a leader in regenerative medicine, announced today the publication of a key study in the American Journal of Physiology Renal Physiology by researchers at Tengion. In the study, rodents with chronic kidney disease (CKD) were treated with healthy kidney cells to catalyze the regeneration of functional kidney tissue and delay disease progression, as evidenced by extended survival, improved kidney filtration, and reduced severity of kidney tissue pathology.

    The published data demonstrate that delivery of a selected population of kidney cells to the kidney significantly extended long-term survival and improved kidney function in rodents with chronic kidney disease during six months of follow-up. Further, the therapeutic effects reported in this study were more pronounced and more durable than have been previously reported with this animal model.

    "These data provide in-vivo proof-of-concept for a potentially transformational approach to preventing kidney failure," said Steven Nichtberger, M.D., president and CEO of Tengion. "Based on these data, over the past two years, Tengion scientists have worked with leaders in the field to design and initiate multiple studies evaluating the ability of our Neo-Kidney Augmentâ„¢ product candidate to prevent kidney failure across a variety of chronic kidney disease models, including large mammals. We look forward to presenting initial scientific findings from these studies in the near future."

    "Chronic kidney disease is a serious medical condition affecting millions of Americans and can lead to kidney failure requiring the need for transplant or lifelong dialysis," said David Gerber, M.D., an advisor to Tengion and Chief, Division of Transplantation, Department of Surgery, University of North Carolina. "A treatment approach that can increase kidney tissue and improve function would be a significant advancement in the care of these patients."

    "The scientific community has historically considered that CKD develops from an imbalance between tissue damage and the kidney's ability to repair and regenerate itself," said Rusty Kelley, Ph.D., Senior Scientist at Tengion and the lead study author. "These preclinical data provide clear evidence that regeneration of functional renal tissue can delay progression of CKD."

    Tengion's Neo−Kidney Augment product candidate is designed to prevent or delay the need for dialysis or kidney transplant in patients with progressive CKD by enhancing functional kidney mass. By using the patient's own kidney cells, procured by a needle biopsy, the Company is developing a product candidate that is implanted into the failing kidney and catalyzes the regeneration of functional kidney tissue. Tengion will provide additional information on its product development plans to investors today at the Rodman & Renshaw Healthcare Conference and slides from that presentation will be available on the Company's website. The Company also expects to share new data from an ongoing study of the Neo-Kidney Augment in a diabetic, obese, hypertensive animal model of renal failure at a meeting of the International Society for Cellular Therapy on September 28, 2010 in San Francisco and to announce the initial results from a study of large animals in the fourth quarter of 2010.

    The paper entitled, "A tubular cell-enriched subpopulation of primary renal cells improves survival and augments kidney function in a rodent model of chronic kidney disease," is available online at the American Journal of Physiology Renal Physiology website - http://ajprenal.physiology.org/cgi/c...l.00221.2010v1 - and will appear in the November 2010 print issue.
    Type II Diabetes & Stage 3 CKD

  • #2
    Re: Study restores kidney function in rodents with CKD

    TYTYTYTYTYTYTYTYTY THANKYOU for your post woooooooohoooooooooooooooooooooooooooooooooooooooo o FINALLY!!!!!!! I LOVE YOU!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
    ckd,stage3,due to birth defect/refulx,controlled b/p

    Comment


    • #3
      Re: Study restores kidney function in rodents with CKD

      You are very welcome Jen! None of us can lose hope....
      Type II Diabetes & Stage 3 CKD

      Comment


      • #4
        Re: Study restores kidney function in rodents with CKD

        I just want to read that article over and over lol.. anyways ya know it would be great if someone on this site lives in san fransisco could go there on sept.28 and emotionally connect maybe they could speak on all our behaves I wish I could go myself but I cant
        ckd,stage3,due to birth defect/refulx,controlled b/p

        Comment


        • #5
          Re: Study restores kidney function in rodents with CKD

          Originally posted by jenjen76 View Post
          I just want to read that article over and over lol.. anyways ya know it would be great if someone on this site lives in san fransisco could go there on sept.28 and emotionally connect maybe they could speak on all our behaves I wish I could go myself but I cant
          Jenjen,

          it's a two day semminar and $450 to attend

          no can do.
          I received the GIFT OF LIFE on Nov 9, 2010 thanks to my wonderful donor Laura and her family!

          Comment


          • #6
            Re: Study restores kidney function in rodents with CKD

            Doesn't this just make you wish you were one of those lucky rats???

            LOL
            Stage 4 Chronic Kidney Disease, 17% renal function, 11 years
            *Non diabetic *Non dialysis
            High Blood Pressure, controlled


            "Never be afraid to trust an unknown future to a known God."
            ~Corrie ten Boom

            Comment


            • #7
              Re: Study restores kidney function in rodents with CKD

              Originally posted by i am blessed View Post
              doesn't this just make you wish you were one of those lucky rats???

              Lol

              hmmmmmmmmmm.................nope
              I received the GIFT OF LIFE on Nov 9, 2010 thanks to my wonderful donor Laura and her family!

              Comment


              • #8
                Re: Study restores kidney function in rodents with CKD

                Oh, you know, I was just a teasing. Glad I'm not a rat either! Besides, cheese isn't allowed and what's a rat's life without cheese? Does anyone remember Risky Rat and Charity the Church Mouse? Cute.
                Stage 4 Chronic Kidney Disease, 17% renal function, 11 years
                *Non diabetic *Non dialysis
                High Blood Pressure, controlled


                "Never be afraid to trust an unknown future to a known God."
                ~Corrie ten Boom

                Comment


                • #9
                  Re: Study restores kidney function in rodents with CKD

                  well heck Ill be the lucky rat its better than this!!!!!!!!!!!!!!
                  ckd,stage3,due to birth defect/refulx,controlled b/p

                  Comment


                  • #10
                    Re: Study restores kidney function in rodents with CKD

                    that stinks that is $450 but I have a question.. If you had enough people like sponsor you ..say send you 10-20$$ each to go could you go? If not I understand I was just thinking I know its hard to come up with the extra $$ I couldnt pull it out of thin air either ..just thought id ask..
                    ckd,stage3,due to birth defect/refulx,controlled b/p

                    Comment


                    • #11
                      Re: Study restores kidney function in rodents with CKD

                      nevermind duhhhhh I lost track of the dates its already the 24th I dont know what I was thinking it wouldnt be enough time to get you the $ maybe another time
                      ckd,stage3,due to birth defect/refulx,controlled b/p

                      Comment


                      • #12
                        Re: Study restores kidney function in rodents with CKD

                        Originally posted by jenjen76 View Post
                        that stinks that is $450 but I have a question.. If you had enough people like sponsor you ..say send you 10-20$$ each to go could you go? If not I understand I was just thinking I know its hard to come up with the extra $$ I couldnt pull it out of thin air either ..just thought id ask..
                        , even if I had the money it would be extremely hard for me. It's an all day event and I do CAPD (4 exchanges/day)
                        I received the GIFT OF LIFE on Nov 9, 2010 thanks to my wonderful donor Laura and her family!

                        Comment

                        Working...
                        X